Hmm. Not sure exactly what you're looking for. Could you say a little more about your criteria?
Most standard guidebooks cover sightseeing in major cities. In general, I usually like Lonely Planet, Let's Go, Rough Guide, etc. slightly better than either Fodor's or Frommer's. The former group tends to be aimed at more active, younger travelers, giving a wider range of cultural information and more low-price options. The latter two may be more upscale and urban, focusing more on business and retirement travel; their restaurant reviews can be helpful, but they tend to devote too much space to hotels and shopping. Michelin is often also worth considering for its nice compact format, if you don't mind small print.
American domestic travelers tend to use the Mobil Travel Guides and/or the AAA ("Triple-A"; American Automobile Association) guidebooks, both of which are published by region. AAA guidebooks are available in AAA offices to members, or perhaps through your own country's automobile association (ADAC or whatever). Both Mobil & AAA are mainly useful for sightseeing information on smaller towns and rural tourist attractions such as state and national parks. On food and lodging they're both fairly downscale, tending more toward motels and family-style dining. They may not include B&Bs (bed and breakfast).
Both Mobil & AAA are aimed mainly at middle-class travelers taking vacations by car, which is the most practical way to go. Travel by train or bus may be slow and inconvenient compared to Europe, except in the largest cities or along a few urban population corridors such as Boston-New York-Philadelphia-Washington D.C. Remember that distances are long: New York to Miami by car, for instance, is around 1300 miles (~2000 km; say, Copenhagen to Naples).