It could depend partly on how personal the, er, issue you're talking about is.
In something like politics, business, or an academic subject, the word is often used for a complicated or controversial problem, a general topic that has several sides or angles. So you could say something like, I wonder if we could find a time to discuss the issue of (research funding, interdepartmental cooperation, women's rights in the 18th century, etc.) more thoroughly / in more detail.
However, in more personal contexts, in pop-psychology or self-help jargon (at least in AE), it can have a negative meaning that's more like 'emotional/neurotic problem.' People might say something like 'He has issues with his mother-in-law' or 'She has a lot of issues about food.' So you might not want to use the word 'issue' alone without being more specific. You could certainly say to someone, I have an issue I'd like to discuss with you, but it might suggest that you were upset or annoyed. So it might be safer, more neutral, just to say 'There's something I'd like to ask you about' or to use the word 'topic' if it's really more objective than subjective.
Sorry, I realize that's all rather vague. It's hard to say in any one case without having a little better idea of the context.