no

Wenn es im Sinne von "aber" verwendet wird, schon, denke ich.

englische kommasetzung unterscheidet sich von der deutschen. link führt zu beispielen...

Niemand außer Dir - nobody but you,
Nichts als Ärger - nothing but trouble

"but" heißt auch "außer" bzw. "als", kein Komma hier!

In der Regel wird im Englischen nur dann ein Komma gesetzt, wenn der darauffolgende Nebensatz vollständig ist, also auch alleine für sich genommen noch Sinn macht.
(stark verallgemeinert!)

http://www.bartleby.com/64/C001/017.html

but beginning a sentence. “In his youth Dostoevsky had been attracted to utopian socialism of the Fourierist variety. But four years in a prison camp in Siberia shook his faith.” As this quotation from J.M. Coetzee shows, the conjunction but can be highly effective as a sentence opener. You may still hear the injunction against beginning a sentence with a conjunction. The idea is that these sentences express “incomplete” thoughts. But a glance through any magazine or newspaper will show you that beginning with but has become common practice, and initial but must be considered acceptable at all levels of style.

but not followed by a comma. But is generally not followed by a comma. Correct written style requires Kim wanted to go, but we stayed, not Kim wanted to go, but, we stayed.

but however. For a discussion of this word combination, see redundancy under Style.

this might shed a bit of light, too